Establishment and Evaluation of a Rat Model of Sidestream Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease
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منابع مشابه
Establishment and Evaluation of a Rat Model of Sidestream Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a common cause of mortality worldwide. The current lack of an animal model that can be established within a certain time frame and imitate the unique features of the disease is a major limiting factor in its study. The present study established and evaluated an animal model of COPD that represents the early and advanced stage features using short-...
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Chronic obstructive pulmonary diseases (COPD), comprised of pulmonary emphysema, chronic bronchitis, and structural and inflammatory changes of small airways, is a leading cause of morbidity and mortality in the world. A better understanding of the pathobiology of COPD is critical for the developing of novel therapies, as the majority of patients with the disease have little therapeutic options...
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lymphocytes and above all in lung epithelial cells [3] . The E1A gene, where the E stands for the fact that it is one of a group of genes transcribed early in the viral life cycle, is responsible for enhancing host infl ammatory mediator expression, because its products are transactivators that function by interacting with numerous cellular transcription factors, transcriptional coactivators an...
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Chronic obstructive pulmonary disease (COPD) is a complex chronic inflammatory disease involving a wide variety of cells and inflammatory mediators. The most important etiological factor in the development of this disease is cigarette smoking. Much of the research into the mechanisms of COPD has been concerned with the induction of inflammation and the role of neutrophils and macrophages in the...
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ژورنال
عنوان ژورنال: Frontiers in Physiology
سال: 2018
ISSN: 1664-042X
DOI: 10.3389/fphys.2018.00058